KMID : 0882420220970030186
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Korean Journal of Medicine 2022 Volume.97 No. 3 p.186 ~ p.190
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Crohn¡¯s Disease Identified as Granulomatous Tubulointerstitial Nephritis
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Han Jung-Suk
Choi Bum-Soon Park Cheol-Whee Choi Yeong-Jin Yang Chul-Woo Lee Han-Hee Ban Tae-Hyun
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Abstract
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Crohn¡¯s disease is usually diagnosed according to intestinal symptoms, but extra-intestinal manifestations are important in approximately one-third of cases. Although several extra-intestinal symptoms associated with various organs have been reported, renal involvement is uncommon in patients with Crohn¡¯s disease. Tubulointerstitial nephritis in a patient with Crohn¡¯s disease is usually caused by infection, sarcoidosis, or medications. However, primary tubulointerstitial nephritis caused by Crohn¡¯s disease alone is extremely rare. A 19-year-old male patient was referred to our hospital because of an increase in serum creatinine level. He underwent a kidney biopsy with renal insufficiency. Renal histological findings revealed granulomatous tubulointerstitial nephritis. Thereafter, a colonoscopy was performed with suspicion of Crohn¡¯s disease. Ultimately, he was diagnosed with granulomatous tubulointerstitial nephritis based on Crohn¡¯s disease. The patient had improved gastrointestinal symptoms after the last treatment. This case report presents a rare case of primary tubulointerstitial nephritis caused by Crohn¡¯s disease.
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KEYWORD
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Inflammatory bowel diseases, Crohn disease, Nephritis, interstitial, Kidney diseases
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